metitepine
Also known as methiothepine, 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine, 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine, (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin, (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin, (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
Metitepine (; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic or tetracyclic group which was never marketed.
Key facts
- Drug.IUPAC_name
- 1-methyl-4-(8-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-6-yl)piperazine
- Drug.image
- Metitepine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225px
- Drug.CAS_number
- 20229-30-5
- Drug.CAS_supplemental
- 19728-88-2 (maleate)
- Drug.PubChem
- 4106
- Drug.IUPHAR_ligand
- 89
- Drug.ChemSpiderID
- 3963
- Drug.ChEBI
- 64203
- Drug.UNII
- 55D94103HL
- Drug.synonyms
- Methiothepin; Methiothepine; Ro 8-6837 (maleate); VUFB-6276 (mesylate)
~3 min read
Article
7 sectionsContents
- Pharmacology
- Pharmacodynamics
- Chemistry
- Analogues
- Synthesis
- References
- External links
Metitepine (; developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic or tetracyclic group which was never marketed.
It acts as a non-selective antagonist of serotonin, dopamine, and adrenergic receptors, including of the serotonin 5-HT1, 5-HT2, 5-HT5, 5-HT6, and 5-HT7 receptors. The drug has antipsychotic properties.