HTR2C

Name

5-hydroxytryptamine receptor 2C

Type

protein-coding

Chromosome

X

Position

114,584,078–114,910,061 (+)

Aliases

5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C

Ensembl

ENSG00000147246

RefSeq RNA

NM_000868.4, NM_001256760.3, NM_001256761.3

RefSeq protein

NP_000859.2, NP_001243689.2, NP_001243690.2

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015].

via MyGene.info

Wikidata facts

Image

HTR2C 8ZMF.png

via Wikidata · CC0