MMP12

Name

matrix metallopeptidase 12

Type

protein-coding

Position

102,862,734–102,874,990 (−)

Aliases

HME, ME, MME, MMP-12

Ensembl

ENSG00000262406

RefSeq RNA

NM_002426.6

RefSeq protein

NP_002417.2

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

matrix metallopeptidase 12

Symbol

MMP12

Biotype

Protein coding

Organism

Homo sapiens

Location

11:102,862,734-102,874,990

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MMP12 PDB 1jiz.png

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