MMP14

Name

matrix metallopeptidase 14

Type

protein-coding

Aliases

MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

matrix metallopeptidase 14

Symbol

MMP14

Biotype

Protein coding

Organism

Homo sapiens

Location

14:22,836,532-22,849,041

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein MMP14 PDB 1bqq.png

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