moxidectin
Sign in to saveAlso known as Moxidectina, Moxidectinum
Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464194650
- Drug.image
- Moxidectin.png
- Drug.image_class
- skin-invert-image
- Drug.alt
- Structural formula of moxidectin
- Drug.width
- 250
- Drug.image2
- Moxidectin 3D ball.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of the moxidectin molecule
- Drug.tradename
- Cydectin, Equest, ProHeart, Quest.
- Drug.routes_of_administration
- By mouth, topical, subcutaneous
- Drug.ATC_prefix
- P02
- Drug.ATC_suffix
- CX03
- Drug.ATC_supplemental
- ,
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.IUPAC_name
- (10E,14E,16E,22Z)-(1R,4S,5′S,6R,6′S,8R,13R,20R,21R,24S)-6′-
via Wikipedia infobox
Research
1,499 papers- Moxidectin: an oral treatment for human onchocerciasis.Expert review of anti-infective therapy · 2020
- Ivermectin and moxidectin against soil-transmitted helminth infections.Trends in parasitology · 2023
- Moxidectin: heartworm disease prevention in dogs in the face of emerging macrocyclic lactone resistance.Parasites & vectors · 2022
- Ivermectin vs moxidectin for treating Strongyloides stercoralis infection: a systematic review.Parasitology · 2024
- Moxidectin versus ivermectin for strongyloidiasis control.The Lancet. Infectious diseases · 2024
via PubMed
Wikidata facts
- Mass
- 639.3771176559998
Show 5 more facts
- chemical formula
- C₃₇H₅₃NO₈
- canonical SMILES
- CC1CC(=CCC2CC(CC3(O2)CC(=NOC)C(C(O3)C(=CC(C)C)C)C)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C
- Commons category
- Moxidectin
- isomeric SMILES
- C[C@@H]1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C/C(=NOC)/[C@@H]([C@H](O3)/C(=C/C(C)C)/C)C)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C
- NCI Thesaurus ID
- C73264
via Wikidata · CC0
~5 min read
Article
6 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- Chemistry
- History
- References
Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Moxidectin is a therapeutic alternative on the World Health Organization's List of Essential Medicines.
Available in 10 languages
via Wikidata sitelinks · CC0