MRPL12

Also known as 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, mitochondrial ribosomal protein L12

protein-coding gene in the species Homo sapiens

Gene data

MRPL12

Name: mitochondrial ribosomal protein L12
Type: protein-coding
Position: 81,703,357–81,711,112 (+)
Aliases: 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, bL12m
Ensembl: ENSG00000262814
RefSeq RNA: NM_002949.4
RefSeq protein: NP_002940.2

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008].