NANS
Sign in to saveAlso known as HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG, SEMDCG
Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.
Gene data
NANS- Name
- N-acetylneuraminate synthase
- Type
- protein-coding
- Aliases
- HEL-S-100, SAS, SEMDCG, SEMDG
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
N-acetylneuraminate synthase
- Symbol
- NANS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:98,056,637-98,084,394
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein NANS PDB 1wvo.png
Show 5 more facts
- HomoloGene ID
- 10343
- genomic end
- 100845357
- exact match
- identifiers.org/ncbigene/54187
- genomic start
- 98056732
- cytogenetic location
- 9q22.33
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.