NEU1
Sign in to saveAlso known as NANH, NEU, SIAL1, neuraminidase 1 (lysosomal sialidase), neuraminidase 1
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.
In the Vinony graph
Vinony's link graph records 327 inbound references to NEU1, and connects out to PubMed, Ensembl genome database project and Wikidata.
It sits within the topics Genes on human chromosome 6 and Human proteins.
Vinony links it to 5 Wikipedia language editions.
Gene data
NEU1- Name
- neuraminidase 1
- Type
- protein-coding
- Position
- 31,857,063–31,862,905 (−)
- Aliases
- NANH, NEU, SIAL1
- Ensembl
- ENSG00000234343
- RefSeq RNA
- NM_000434.4
- RefSeq protein
- NP_000425.1
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
neuraminidase 1
- Symbol
- NEU1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MCF_CTG1:3,199,729-3,204,976
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- C1-inhibitor.png
Show 8 more facts
- HomoloGene ID
- 375
- genomic start
- 31825436
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4758
- chromosome
- human chromosome 6
- genomic end
- 31862905
- cytogenetic location
- 6p21.33
- expressed in
- renal cortex
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Clinical significance
- Interactions
- References
- Further reading
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.
== Function ==
Excerpted from Wikipedia’s “NEU1” article, available under the CC BY-SA 4.0 licence.