nelivaptan

Also known as SSR-149,415, SSR149415

Nelivaptan (INN) (developmental codename SSR-149,415) is a selective, orally active, non-peptide vasopressin receptor antagonist selective for the V1B subtype. The drug had entered clinical trials for treatment of anxiety and depression. In July 2008, Sanofi-Aventis announced that further development of this drug had been halted.

In the Vinony graph

Within Vinony's link graph, nelivaptan is referenced by 64 other articles, and connects out to arginine vasopressin, oral administration and World Health Organization.

Vinony files it under Abandoned drugs, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.

Its subject is documented across 5 Wikipedia language editions.

Chemical data

Formula: C30H32ClN3O8S
Molecular weight: 630.1 g/mol
IUPAC name: (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide
SMILES: CN(C)C(=O)[C@@H]1C[C@H](CN1[C@]2(C3=C(C=CC(=C3)Cl)N(C2=O)S(=O)(=O)C4=C(C=C(C=C4)OC)OC)C5=CC=CC=C5OC)O
InChIKey: NJXZWIIMWNEOGJ-WEWKHQNJSA-N
XLogP: 3.4
Polar surface area: 134 Å²
H-bond donors: 1
H-bond acceptors: 9
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: anxiety, depressive disorder

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 629.16

Show 3 more facts

chemical formula: C₃₀H₃₂ClN₃O₈S
isomeric SMILES: CN(C)C(=O)[C@@H]1C[C@H](CN1[C@]2(C3=C(C=CC(=C3)Cl)N(C2=O)S(=O)(=O)C4=C(C=C(C=C4)OC)OC)C5=CC=CC=C5OC)O
canonical SMILES: CN(C)C(=O)C1CC(CN1C2(C3=C(C=CC(=C3)Cl)N(C2=O)S(=O)(=O)C4=C(C=C(C=C4)OC)OC)C5=CC=CC=C5OC)O

Sources (2)

via Wikidata · CC0

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