nitecapone

Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It was patented as an antiparkinson medication but was never marketed.

In the Vinony graph

Vinony's link graph records 195 inbound references to nitecapone, and connects out to L-tyrosine, catechol-O-methyltransferase and 3-methoxy-4-hydroxyphenylglycol.

It is catalogued under topics including Antiparkinsonian agents, Catechol-O-methyltransferase inhibitors and Catechols.

Vinony links it to 4 Wikipedia language editions.

Chemical data

Formula: C12H11NO6
Molecular weight: 265.22 g/mol
IUPAC name: 3-[(3,4-dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione
SMILES: CC(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C(=O)C
InChIKey: UPMRZALMHVUCIN-UHFFFAOYSA-N
XLogP: 1.2
Polar surface area: 120 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 265.059
Has use: medication

Show 4 more facts

chemical formula: C₁₂H₁₁NO₆
canonical SMILES: CC(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C(=O)C
subject has role: antioxidant
Commons category: Nitecapone

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Encyclopedic overview

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Contents

See also
References

Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It was patented as an antiparkinson medication but was never marketed.

==See also== List of investigational Parkinson's disease drugs Catechol-O-methyltransferase inhibitor

Excerpted from Wikipedia’s “nitecapone” article, available under the CC BY-SA 4.0 licence.