Structure via PubChem · Public domain (PubChem)
aceprometazine
Sign in to saveAlso known as Acepromethazine, 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone, CB-1664, Aceprometazina, Aceprometazinum, Mepronizine
Aceprometazine (INN) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties It is not widely prescribed, and may be associated with drug-induced Parkinsonism. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.
Chemical data
- Formula
- C19H22N2OS
- Molecular weight
- 326.5 g/mol
- IUPAC name
- 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
- SMILES
- CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
- InChIKey
- XLOQNFNTQIRSOX-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 48.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
6 papers- Meprobamate-induced fixed drug eruption.Current drug safety · 2014
- Abusive prescription of psychostimulants: a study of two cases.Journal of forensic sciences · 2006
- Risk of syncope in the elderly and consumption of drugs: a case-control study.Journal of clinical epidemiology · 1997
- [Severe meprobamate poisoning: description of 146 cases in a French department].Therapie · 2012
- Electro-encephalographic study on the action of the combination meprobamate-aceprometazine on various cerebral systems.Arzneimittel-Forschung · 1974
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 326.145284
- Has use
- medication
Show 6 more facts
- different from
- acepromazine
- chemical formula
- C₁₉H₂₂N₂OS
- canonical SMILES
- CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
- World Health Organisation international non-proprietary name
- aceprometazine
- subject has role
- dopamine antagonist
- Commons category
- Aceprometazine
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
{{Drugbox | verifiedrevid = 477238377 | IUPAC_name = 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone | image = Aceprometazine.svg | image_class = skin-invert-image
| tradename = | pregnancy_category = ContraindicatedPasses into breast milk | legal_status = Rx-only | routes_of_administration = Oral
Excerpted from Wikipedia’s “aceprometazine” article, available under the CC BY-SA 4.0 licence.