aceprometazine

Also known as Acepromethazine, 10-(2-(Dimethylamino)propyl)phenothiazin-2-yl methyl ketone, CB-1664, Aceprometazina, Aceprometazinum, Mepronizine

Aceprometazine (INN) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties It is not widely prescribed, and may be associated with drug-induced Parkinsonism. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

In the Vinony graph

Vinony's link graph records 445 inbound references to aceprometazine, and connects out to France, liver and medication.

Vinony files it under Aromatic ketones, D2 antagonists and Drugs not assigned an ATC code.

Vinony links it to 4 Wikipedia language editions.

Chemical data

Formula: C19H22N2OS
Molecular weight: 326.5 g/mol
IUPAC name: 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
InChIKey: XLOQNFNTQIRSOX-UHFFFAOYSA-N
XLogP: 4.3
Polar surface area: 48.9 Å²
H-bond donors: 0
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

6 papers

Meprobamate-induced fixed drug eruption.Current drug safety · 2014
Abusive prescription of psychostimulants: a study of two cases.Journal of forensic sciences · 2006
Risk of syncope in the elderly and consumption of drugs: a case-control study.Journal of clinical epidemiology · 1997
[Severe meprobamate poisoning: description of 146 cases in a French department].Therapie · 2012
Electro-encephalographic study on the action of the combination meprobamate-aceprometazine on various cerebral systems.Arzneimittel-Forschung · 1974

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 326.145284
Has use: medication

Show 6 more facts

different from: acepromazine
chemical formula: C₁₉H₂₂N₂OS
canonical SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(=O)C)N(C)C
World Health Organisation international non-proprietary name: aceprometazine
subject has role: dopamine antagonist
Commons category: Aceprometazine

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

2 sections

Contents

Synthesis
References

{{Drugbox | verifiedrevid = 477238377 | IUPAC_name = 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone | image = Aceprometazine.svg | image_class = skin-invert-image

| tradename = | pregnancy_category = ContraindicatedPasses into breast milk | legal_status = Rx-only | routes_of_administration = Oral

Excerpted from Wikipedia’s “aceprometazine” article, available under the CC BY-SA 4.0 licence.