Structure via PubChem · Public domain (PubChem)
acepromazine
Sign in to saveAlso known as Acetazine, 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone, 1-[10-(3-DIMETHYLAMINO-propyl)-10H-phenothiazin-2-yl]-ethanone, 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone, Acetopromazine, Acetylpromazine
Acepromazine, acetopromazine, or acetylpromazine (commonly known as ACP, Ace, or by the trade names Atravet or Acezine 2, number depending on mg/ml dose) is a phenothiazine derivative antipsychotic drug. It was used in humans during the 1950s as an antipsychotic, but is now almost exclusively used on animals as a sedative and antiemetic. A closely related analogue, chlorpromazine, is still used in humans.
In the Vinony graph
Vinony's link graph records 510 inbound references to acepromazine, and connects out to propranolol, fluphenazine and zuclopenthixol.
It sits within the topics Alpha-1 blockers, Antiemetics and Aromatic ketones.
Vinony links it to 18 Wikipedia language editions.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477238349
- Drug.IUPAC_name
- 1-{10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
- Drug.image
- Acepromazine.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Atravet, Acezine 2
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
- Drug.legal_CA
- OTC
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- 6.6 L/kg, high volume of distribution
- Drug.elimination_half life
- 3 hours in horses, 15.9 hours in canines
- Drug.excretion
- urine
- Drug.CAS_number
- 61-00-7
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AA04
- Drug.PubChem
- 6077
- Drug.DrugBank
- DB01614
via Wikipedia infobox
Chemical data
- Formula
- C19H22N2OS
- Molecular weight
- 326.5 g/mol
- IUPAC name
- 1-[10-[3-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
- SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C
- InChIKey
- NOSIYYJFMPDDSA-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 48.9 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Research
1,399 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 326.145
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₉H₂₂N₂OS
- Commons category
- Acepromazine
- canonical SMILES
- CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C
- subject has role
- dopamine antagonist
- defined daily dose
- 50
via Wikidata · CC0
~9 min read
Encyclopedic overview
9 sectionsContents
- Pharmacology
- Veterinary use
- Canine and feline
- Adverse effects in cats
- Adverse effects in dogs
- Dogs with a mutation in the ''ABCB1'' (''MDR1'') gene
- Equine
- Adverse effects
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 477238349 | IUPAC_name = 1-{10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone | image = Acepromazine.svg | image_class = skin-invert-image
| tradename = Atravet, Acezine 2 | Drugs.com = | legal_AU = S4 | legal_BR = C1 | legal_BR_comment = | legal_CA = OTC | legal_US = Rx-only | legal_UK = POM | legal_status = | routes_of_administration = IV, IM, SQ, oral
Excerpted from Wikipedia’s “acepromazine” article, available under the CC BY-SA 4.0 licence.