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Structure via PubChem · Public domain (PubChem)
Netupitant
Sign in to saveAlso known as Ro 67-31898/000, Ro-673189000, 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide
senyawa kimia
Chemical data
- Formula
- C30H32F6N4O
- Molecular weight
- 578.6 g/mol
- IUPAC name
- 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)-3-pyridinyl]propanamide
- SMILES
- CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
- InChIKey
- WAXQNWCZJDTGBU-UHFFFAOYSA-N
- XLogP
- 6.8
- Polar surface area
- 39.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2014
- Admin. routes
- oral
- Indications
- Chemotherapy-induced nausea and vomiting, cancer
via ChEMBL · EBI
Research
222 papers- Netupitant/Palonosetron: A Review in Chemotherapy-Induced Nausea and Vomiting.Drugs · 2021
- Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice.Current cancer drug targets · 2022
- Netupitant/Palonosetron: A Review in the Prevention of Chemotherapy-Induced Nausea and Vomiting.Drugs · 2015
- Netupitant/palonosetron (Akynzeo) for chemotherapy-induced nausea and vomiting.The Medical letter on drugs and therapeutics · 2015
- Netupitant/Palonosetron.Hospital pharmacy · 2015
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 578.248031
- Has use
- medication
Show 4 more facts
- chemical formula
- C₃₀H₃₂F₆N₄O
- canonical SMILES
- CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C
- World Health Organisation international non-proprietary name
- netupitant
- Commons category
- Netupitant
via Wikidata · CC0