oxyclozanide
Sign in to saveOxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants, mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes. Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".
Research
147 papers- Dietary oxyclozanide influences antioxidant enzyme activities and damages DNA in Galleria mellonella (Lepidoptera: Pyralidae).Environmental entomology · 2024
- Pharmacokinetics and pharmacokinetic interactions of orally administered oxfendazole and oxyclozanide tablet formulation to sheep.Journal of veterinary pharmacology and therapeutics · 2023
- Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats.Frontiers in veterinary science · 2019
- The anthelmintic oxyclozanide restores the activity of colistin against colistin-resistant Gram-negative bacilli.International journal of antimicrobial agents · 2019
- The ionophore oxyclozanide enhances tobramycin killing of Pseudomonas aeruginosa biofilms by permeabilizing cells and depolarizing the membrane potential.The Journal of antimicrobial chemotherapy · 2019
via PubMed
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Encyclopedic overview
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Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants, mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes. Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".
Sometimes alluded to as "Pentaclosamide": CN101891646.
Excerpted from Wikipedia’s “oxyclozanide” article, available under the CC BY-SA 4.0 licence.