PDLIM2
Sign in to saveAlso known as MYSTIQUE, SLIM, PDZ and LIM domain 2
PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene.
Gene data
PDLIM2- Name
- PDZ and LIM domain 2
- Type
- protein-coding
- Position
- 22,578,058–22,598,025 (+)
- Aliases
- MYSTIQUE, SLIM
- Ensembl
- ENSG00000120913
- RefSeq RNA
- NM_001368120.1, NM_021630.6, NM_176871.5, NM_198042.4
- RefSeq protein
- NP_001355049.1, NP_067643.3, NP_789847.1, NP_932159.1
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
PDZ and LIM domain 2
- Symbol
- PDLIM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:22,578,058-22,598,025
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PDLIM2 PDB 2pa1.png
Show 5 more facts
- HomoloGene ID
- 11006
- exact match
- identifiers.org/ncbigene/64236
- genomic end
- 22455538
- genomic start
- 22435792
- cytogenetic location
- 8p21.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene.
==References==