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GeneQ18042943· pop 8· linked from 3 articles

PELI2

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Also known as pellino E3 ubiquitin protein ligase family member 2

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to PELI2, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 14.

Vinony links it to 8 Wikipedia language editions.

Gene data

PELI2

Name: pellino E3 ubiquitin protein ligase family member 2
Type: protein-coding
Position: 56,117,814–56,301,746 (+)
Ensembl: ENSG00000139946
RefSeq RNA: NM_021255.3, XM_005267890.6, XM_006720211.4, XM_011536990.3, XM_011536992.4
RefSeq protein: NP_067078.1, XP_005267947.1, XP_006720274.1, XP_011535292.1, XP_011535294.1

Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

protein polyubiquitination protein polyubiquitination positive regulation of protein phosphorylation regulation of Toll signaling pathway protein ubiquitination positive regulation of canonical NF-kappaB signal transduction positive regulation of canonical NF-kappaB signal transduction positive regulation of MAPK cascade

Molecular function

protein binding ubiquitin-ubiquitin ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity phosphorylation-dependent protein binding

Cellular component

Pathways

Cytokine Signaling in Immune system Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System

via MyGene.info

Gene · Ensembl

pellino E3 ubiquitin protein ligase family member 2

Symbol: PELI2
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:56,117,814-56,301,746
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein PELI2 PDB 3EGA.png

Show 8 more facts

HomoloGene ID: 41431
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57161
genomic end: 56301524
genomic start: 56584532
chromosome: human chromosome 14
cytogenetic location: 14q22.3
expressed in: sural nerve

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.

==References==

Excerpted from Wikipedia’s “PELI2” article, available under the CC BY-SA 4.0 licence.

Available in 8 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 14