pertuzumab
Sign in to saveAlso known as 2C4 Antibody, MOAB 2C4, Monoclonal Antibody 2C4, Omnitarg, rhuMAb-2C4, RG-1273
Pertuzumab, sold under the brand name Perjeta among others, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.
Key facts
- Drug.type
- mab
- Drug.image
- Pertuzumab-HER2 complex 1S78.png
- Drug.caption
- The structure of HER2 and pertuzumab
- Drug.mab_type
- mab
- Drug.source
- zu/o
- Drug.target
- HER2
- Drug.tradename
- Perjeta
- Drug.MedlinePlus
- a612027
- Drug.DailyMedID
- Pertuzumab
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Intravenous
- Drug.class
- Antineoplastic
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- FD02
- Drug.biosimilars
- pertuzumab-dpzb, Poherdy
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
via Wikipedia infobox
~8 min read
Encyclopedic overview
15 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- Mechanism of action
- Chemistry and manufacturing
- History
- Clinical Trials
- APHINITY study
- Society and culture
- Legal status
- Biosimilars
- Economics
- References
- Further reading
- External links
Pertuzumab, sold under the brand name Perjeta among others, is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.
Side effects in more than half the people taking it include diarrhea, hair loss, and loss of neutrophils; more than 10% experience loss of red blood cells, hypersensitivity or allergic reaction, infusion reactions, decreased appetite, insomnia, distortions in the sense of taste, inflammation of the mouth or lips, constipation, rashes, nail disease, and muscle pain. Women who are pregnant or planning on getting pregnant should not take it, it was not studied in people with certain heart conditions and should be used in caution in such people, and it should not be used with an anthracycline. It is unknown if pertuzumab interacts with doxorubicin.
Excerpted from Wikipedia’s “pertuzumab” article, available under the CC BY-SA 4.0 licence.