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phenylsilatrane
Sign in to savePhenylsilatrane is a convulsant chemical which has been used as a rodenticide. Phenylsilatrane and some of its analogs with 4-substituents of H, CH3, Cl, Br, and CSi(CH3)3 are highly toxic to mice. They have been observed in the laboratory to inhibit the 35S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.
Chemical data
- Formula
- C12H17NO3Si
- Molecular weight
- 251.35 g/mol
- IUPAC name
- 1-phenyl-2,8,9-trioxa-5-azonia-1-silanuidatricyclo[3.3.3.01,5]undecane
- SMILES
- C1CO[Si-]23([N+]1(CCO2)CCO3)C4=CC=CC=C4
- InChIKey
- LDOWJVBCZRHOKX-UHFFFAOYSA-N
- Polar surface area
- 27.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 251.09777
Show 4 more facts
- melting point
- 211
- chemical formula
- C₁₂H₁₇NO₃Si
- canonical SMILES
- C1CO[Si-]23([N+]1(CCO2)CCO3)C4=CC=CC=C4
- Commons category
- Phenyl silatrane
Sources (1)
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Encyclopedic overview
2 sectionsContents
- See also
- References
Phenylsilatrane is a convulsant chemical which has been used as a rodenticide. Phenylsilatrane and some of its analogs with 4-substituents of H, CH3, Cl, Br, and CSi(CH3)3 are highly toxic to mice. They have been observed in the laboratory to inhibit the 35S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.
== See also == Atrane GABAA receptor negative allosteric modulator GABAA receptor § Ligands Chlorophenylsilatrane
Excerpted from Wikipedia’s “phenylsilatrane” article, available under the CC BY-SA 4.0 licence.
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