pholcodine
Sign in to saveAlso known as 3-morpholinoethylmorphine, morpholinylethylmorphine, 3-(2-morpholinoethyl)morphine, beta-morpholinoethylmorphine, tetrahydro-1,4-oxazinylmethylcodeine, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholinoethoxy)morphinan-6-alpha-ol, 3-(2-(4-morpholinyl)ethyl)morphine
Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs and also has a mild sedative effect, but has little or no analgesic effects. It is also known as morpholinylethylmorphine and homocodeine.
Key facts
- Drug.image
- Pholcodine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Pholcodine3DanJ.gif
- Drug.width2
- 250
- Drug.tradename
- Logicin, others
- Drug.addiction_liability
- High
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- R05
- Drug.ATC_suffix
- DA08
- Drug.legal_BR
- A2
- Drug.legal_CA
- Schedule I
- Drug.legal_DE
- Anlage II
- Drug.legal_UK
- Class B
- Drug.legal_US
- Schedule I
- Drug.bioavailability
- Maximum plasma conc. attained 4-8 hours after oral dose.
- Drug.protein_bound
- 23.5%
- Drug.metabolism
- Liver
via Wikipedia infobox
Research
145 papers- Pholcodine.Journal of clinical pharmacy and therapeutics · 1988
- Pholcodine and allergy to neuromuscular blocking agents: where are we and how did we get here?British journal of anaesthesia · 2024
- Pholcodine exposure increases the risk of perioperative anaphylaxis to neuromuscular blocking agents: the ALPHO case-control study.British journal of anaesthesia · 2023
- Cough up, time's up: pholcodine and risk of anaphylaxis to general anaesthetics.Archives of disease in childhood · 2023
- Safety update: withdrawal of pholcodine-containing medicines.Drug and therapeutics bulletin · 2023
via PubMed
Wikidata facts
- Mass
- 398.220557
Show 6 more facts
- chemical formula
- C₂₃H₃₀N₂O₄
- isomeric SMILES
- CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OCCN6CCOCC6)O[C@H]3[C@H](C=C4)O
- canonical SMILES
- CN1CCC23C4C1CC5=C2C(=C(C=C5)OCCN6CCOCC6)OC3C(C=C4)O
- World Health Organisation international non-proprietary name
- pholcodine
- Commons category
- Pholcodine
- defined daily dose
- 50
Sources (3)
via Wikidata · CC0
~6 min read
Article
5 sectionsContents
- Mechanism of action
- Metabolism and excretion
- Side effects
- Anaphylaxis during general anaesthesia
- References
Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs and also has a mild sedative effect, but has little or no analgesic effects. It is also known as morpholinylethylmorphine and homocodeine.
Pholcodine is found in certain cough lozenges, and more commonly as an oral solution, typically 5 mg / 5 ml. Adult dosage is 5-10 ml up to 3-4 times daily. Pholcodine now largely replaces the previously more common codeine linctus, as it has a much lower potential for dependence.