Structure via PubChem · Public domain (PubChem)
piminodine
Sign in to savePiminodine (Alvodine) is an opioid analgesic that is an analogue of pethidine (meperidine). It was used in medicine briefly during the 1960s and 70s, but has largely fallen out of clinical use. It was used particularly for obstetric analgesia and in dental procedures and, like pethidine, could be combined with hydroxyzine to intensify the effects. The duration of action is 2–4 hours; 7.5–10 mg via the subcutaneous route is the most common starting dose, being equal to 80–100 mg of pethidine, 40–60 mg of alphaprodine and 10 mg of morphine. Oral formulations were also availab
In the Vinony graph
Vinony's link graph records 827 inbound references to piminodine, and connects out to (+)-catechin, butorphanol and prodine.
It sits within the topics Anilines, Carboxylate esters and Chemical pages without DrugBank identifier.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C23H30N2O2
- Molecular weight
- 366.5 g/mol
- IUPAC name
- ethyl 1-(3-anilinopropyl)-4-phenylpiperidine-4-carboxylate
- SMILES
- CCOC(=O)C1(CCN(CC1)CCCNC2=CC=CC=C2)C3=CC=CC=C3
- InChIKey
- PXXKIYPSXYFATG-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 41.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 366.231
Show 2 more facts
- chemical formula
- C₂₃H₃₀N₂O₂
- canonical SMILES
- CCOC(=O)C1(CCN(CC1)CCCNC2=CC=CC=C2)C3=CC=CC=C3
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Piminodine (Alvodine) is an opioid analgesic that is an analogue of pethidine (meperidine). It was used in medicine briefly during the 1960s and 70s, but has largely fallen out of clinical use. It was used particularly for obstetric analgesia and in dental procedures and, like pethidine, could be combined with hydroxyzine to intensify the effects. The duration of action is 2–4 hours; 7.5–10 mg via the subcutaneous route is the most common starting dose, being equal to 80–100 mg of pethidine, 40–60 mg of alphaprodine and 10 mg of morphine. Oral formulations were also available.
Piminodine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.
Excerpted from Wikipedia’s “piminodine” article, available under the CC BY-SA 4.0 licence.