PMM1

Also known as Sec53, phosphomannomutase 1, PMMH-22, PMM 1

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

Gene data

PMM1

Name: phosphomannomutase 1
Type: protein-coding
Position: 41,576,896–41,595,275 (−)
Aliases: PMM 1, PMMH-22, Sec53
Ensembl: ENSG00000100417
RefSeq RNA: NM_002676.3, XM_005261638.5, XM_011530229.3, XM_011530230.3, XM_011530231.4
RefSeq protein: NP_002667.2, XP_005261695.1, XP_011528531.1, XP_011528532.1, XP_011528533.1

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mannose metabolic process mannose metabolic process

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Article

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Contents

References
Further reading

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.