Gene data
PPL- Name
- periplakin
- Type
- protein-coding
- Position
- 4,879,449–4,960,741 (−)
- Ensembl
- ENSG00000118898
- RefSeq RNA
- NM_002705.5, XM_006720902.5, XM_017023374.3, XM_017023375.3, XM_054380583.1
- RefSeq protein
- NP_002696.4, XP_006720965.1, XP_016878863.1, XP_016878864.1, XP_054236558.1
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
periplakin
- Symbol
- PPL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:4,879,449-4,960,741
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 2026
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5493
- genomic end
- 5010742
- genomic start
- 4932508
- chromosome
- human chromosome 16
- cytogenetic location
- 16p13.3
- expressed in
- Human penis
Sources (4)
via Wikidata · CC0