PTPN14
Sign in to saveAlso known as PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2
Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.
Gene data
PTPN14- Name
- protein tyrosine phosphatase non-receptor type 14
- Type
- protein-coding
- Position
- 214,348,700–214,552,449 (−)
- Aliases
- CATLPH, PEZ, PTP36, PTPD2
- Ensembl
- ENSG00000152104
- RefSeq RNA
- NM_005401.5, XM_017001941.2, XM_024448759.2, XM_047426367.1, XM_047426370.1
- RefSeq protein
- NP_005392.2, XP_016857430.1, XP_024304527.1, XP_047282323.1, XP_047282326.1
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
protein tyrosine phosphatase non-receptor type 14
- Symbol
- PTPN14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:214,348,700-214,552,449
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.
== Function ==
Excerpted from Wikipedia’s “PTPN14” article, available under the CC BY-SA 4.0 licence.