REG3G

Also known as LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

Gene data

REG3G

Name: regenerating family member 3 gamma
Type: protein-coding
Position: 79,025,686–79,028,505 (+)
Aliases: LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429
Ensembl: ENSG00000143954
RefSeq RNA: NM_001008387.3, NM_001270040.2, NM_198448.4, XM_005264135.3, XM_024452693.2
RefSeq protein: NP_001008388.1, NP_001256969.1, NP_940850.1, XP_005264192.1, XP_024308461.1

This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014].

Gene Ontology

Biological process

MyD88-dependent toll-like receptor signaling pathway

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Notes and references
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Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.