REG3G

Also known as LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

In the Vinony graph

Vinony's link graph records 7 inbound references to REG3G, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Vinony links it to 7 Wikipedia language editions.

Gene data

REG3G

Name: regenerating family member 3 gamma
Type: protein-coding
Position: 79,025,686–79,028,507 (+)
Aliases: LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429
Ensembl: ENSG00000143954
RefSeq RNA: NM_001008387.3, NM_001270040.2, NM_198448.4, XM_005264135.3, XM_024452693.2
RefSeq protein: NP_001008388.1, NP_001256969.1, NP_940850.1, XP_005264192.1, XP_024308461.1

This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014].

Gene Ontology

Biological process

MyD88-dependent toll-like receptor signaling pathway positive regulation of cell population proliferation positive regulation of keratinocyte proliferation response to peptide hormone negative regulation of keratinocyte differentiation defense response to Gram-positive bacterium antimicrobial humoral immune response mediated by antimicrobial peptide antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

hormone activity growth factor activity carbohydrate binding peptidoglycan binding oligosaccharide binding

Cellular component

extracellular region extracellular region extracellular region extracellular region cytoplasm cytoplasm

Pathways

Innate Immune System Immune System Antimicrobial peptides

via MyGene.info

Gene · Ensembl

regenerating family member 3 gamma

Symbol: REG3G
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:79,025,686-79,028,507
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 128216
exact match: identifiers.org/ncbigene/130120
found in taxon: Homo sapiens
chromosome: human chromosome 2
genomic start: 79252812
genomic end: 79255631
cytogenetic location: 2p12

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

Notes and references
Bibliography

Regenerating islet-derived protein 3 gamma (also Regenerating islet-derived protein III-gamma) is a protein that in humans is encoded by the REG3G gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.

Excerpted from Wikipedia’s “REG3G” article, available under the CC BY-SA 4.0 licence.