RNF34
Sign in to saveAlso known as CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
Gene data
RNF34- Name
- ring finger protein 34
- Type
- protein-coding
- Aliases
- CARP-1, CARP1, RFI, RIF, RIFF, hRFI
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012].
via MyGene.info
Gene · Ensembl
ring finger protein 34
- Symbol
- RNF34
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:121,400,078-121,446,466
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11839
- exact match
- identifiers.org/ncbigene/80196
- genomic start
- 121400083
- genomic end
- 121868389
- cytogenetic location
- 12q24.31
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.