CHFR
Sign in to saveAlso known as RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, checkpoint with forkhead and ring finger domains
E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.
Gene data
CHFR- Name
- checkpoint with forkhead and ring finger domains
- Type
- protein-coding
- Aliases
- RNF116, RNF196
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].
via MyGene.info
Gene · Ensembl
checkpoint with forkhead and ring finger domains
- Symbol
- CHFR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:132,822,187-132,956,304
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CHFR PDB 1lgp.png
Show 5 more facts
- HomoloGene ID
- 10078
- genomic end
- 133532890
- exact match
- identifiers.org/ncbigene/55743
- genomic start
- 133398773
- cytogenetic location
- 12q24.33
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- External links
- Further reading
E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.
CHFR is recruited to sites of DNA damage and participates in the DNA damage response. CHFR has an important role in the survival of male premeiotic germ cells. About 30% of male CHFR knockout mice are infertile. In these knockout mice spermatogenesis onset is delayed and apoptosis in premeiotic germ cells is significantly increased. When these mice are 3 months old there is a complete loss of germ cells in their testes.