CHFR

Also known as RNF116, RNF196, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase, checkpoint with forkhead and ring finger domains

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to CHFR, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 4 Wikipedia language editions.

Gene data

CHFR

Name: checkpoint with forkhead and ring finger domains
Type: protein-coding
Position: 132,822,187–132,956,304 (−)
Aliases: RNF116, RNF196
Ensembl: ENSG00000072609
RefSeq RNA: NM_001161344.1, NM_001161345.1, NM_001161346.2, NM_001161347.1, NM_018223.2
RefSeq protein: NP_001154816.1, NP_001154817.1, NP_001154818.1, NP_001154819.1, NP_060693.2

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].

Gene Ontology

Biological process

mitotic cell cycle ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process protein ubiquitination meiotic spindle checkpoint signaling mitotic G2/M transition checkpoint mitotic G2/M transition checkpoint

Molecular function

nucleotide binding ubiquitin-protein transferase activity ubiquitin-protein transferase activity protein binding ubiquitin protein ligase activity

Cellular component

nucleus nucleus PML body PML body

via MyGene.info

Gene · Ensembl

checkpoint with forkhead and ring finger domains

Symbol: CHFR
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:132,822,187-132,956,304
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CHFR PDB 1lgp.png

Show 8 more facts

HomoloGene ID: 10078
genomic end: 133532890
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/55743
genomic start: 133398773
chromosome: human chromosome 12
cytogenetic location: 12q24.33
expressed in: spleen

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.

CHFR is recruited to sites of DNA damage and participates in the DNA damage response. CHFR has an important role in the survival of male premeiotic germ cells. About 30% of male CHFR knockout mice are infertile. In these knockout mice spermatogenesis onset is delayed and apoptosis in premeiotic germ cells is significantly increased. When these mice are 3 months old there is a complete loss of germ cells in their testes.

Excerpted from Wikipedia’s “CHFR” article, available under the CC BY-SA 4.0 licence.