ROBO3

Also known as HGPPS, HGPS, RBIG1, RIG1, roundabout guidance receptor 3, HGPPS1

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.

In the Vinony graph

Within Vinony's link graph, ROBO3 is referenced by 12 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ROBO3

Name: roundabout guidance receptor 3
Type: protein-coding
Position: 124,865,413–124,881,471 (+)
Aliases: HGPPS, HGPPS1, HGPS, RBIG1, RIG1
Ensembl: ENSG00000154134
RefSeq RNA: NM_001370356.1, NM_001370357.1, NM_001370358.1, NM_001370359.1, NM_001370361.1
RefSeq protein: NP_001357285.1, NP_001357286.1, NP_001357287.1, NP_001357288.1, NP_001357290.1

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019].