TSHZ3

Also known as TSH3, ZNF537, teashirt zinc finger homeobox 3

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene. In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

In the Vinony graph

Vinony's link graph records 811 inbound references to TSHZ3, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 19.

Vinony links it to 5 Wikipedia language editions.

Gene data

TSHZ3

Name: teashirt zinc finger homeobox 3
Type: protein-coding
Position: 31,149,979–31,349,814 (−)
Aliases: TSH3, ZNF537
Ensembl: ENSG00000121297
RefSeq RNA: NM_020856.4, NR_138034.2, NR_138035.2, NR_138036.2, XM_047439132.1
RefSeq protein: NP_065907.2, XP_047295088.1

This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016].

Gene Ontology

Biological process

regulation of respiratory gaseous exchange by nervous system process regulation of respiratory gaseous exchange by nervous system process regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of DNA-templated transcription positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation

Molecular function

DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding DNA binding chromatin binding protein binding

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm growth cone

via MyGene.info

Gene · Ensembl

teashirt zinc finger homeobox 3

Symbol: TSHZ3
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:31,149,979-31,349,814
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TSHZ3 PDB 2dmi.png

Show 7 more facts

HomoloGene ID: 10835
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57616
genomic end: 31349436
chromosome: human chromosome 19
genomic start: 31149979
cytogenetic location: 19q12

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz3 is being studied for its relationship to infant breathing defects in humans.

Excerpted from Wikipedia’s “TSHZ3” article, available under the CC BY-SA 4.0 licence.