TELO2
Sign in to saveAlso known as CLK2, TEL2, telomere maintenance 2, YHFS
Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.
Gene data
TELO2- Name
- telomere maintenance 2
- Type
- protein-coding
- Aliases
- CLK2, TEL2, YHFS
This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009].
via MyGene.info
Gene · Ensembl
telomere maintenance 2
- Symbol
- TELO2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:1,493,329-1,512,551
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 41107
- genomic start
- 1543345
- exact match
- identifiers.org/ncbigene/9894
- genomic end
- 1560458
- cytogenetic location
- 16p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- References
- Further reading
- External links
Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.
==Function== In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR and is a highly conserved regulator of PIKK stability.