TELO2

Also known as CLK2, TEL2, telomere maintenance 2, YHFS

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to TELO2, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 16 and Telomere-related proteins.

Vinony links it to 6 Wikipedia language editions.

Gene data

TELO2

Name: telomere maintenance 2
Type: protein-coding
Position: 1,493,329–1,512,551 (+)
Aliases: CLK2, TEL2, YHFS
Ensembl: ENSG00000100726
RefSeq RNA: NM_001351846.2, NM_016111.4, XM_011522773.4, XM_011522774.3, XM_011522775.4
RefSeq protein: NP_001338775.1, NP_057195.2, XP_011521075.1, XP_011521076.1, XP_011521077.1

This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009].

Pathways

Fanconi anemia pathway - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)Fragile X Syndrome

via MyGene.info

Gene · Ensembl

telomere maintenance 2

Symbol: TELO2
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:1,493,329-1,512,551
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 41107
genomic start: 1543345
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9894
chromosome: human chromosome 16
genomic end: 1560458
cytogenetic location: 16p13.3
expressed in: anterior pituitary

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.

==Function== In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR and is a highly conserved regulator of PIKK stability.

Excerpted from Wikipedia’s “TELO2” article, available under the CC BY-SA 4.0 licence.