S1PR5
Sign in to saveAlso known as EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, sphingosine-1-phosphate receptor 5
Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.
Gene data
S1PR5- Name
- sphingosine-1-phosphate receptor 5
- Type
- protein-coding
- Aliases
- EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008].
via MyGene.info
Gene · Ensembl
sphingosine-1-phosphate receptor 5
- Symbol
- S1PR5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:10,512,742-10,517,981
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11031
- exact match
- identifiers.org/ncbigene/53637
- genomic end
- 10628607
- genomic start
- 10623623
- cytogenetic location
- 19p13.2
Sources (3)
via Wikidata · CC0
~1 min read
Article
7 sectionsContents
- Agonists
- Evolution
- [[Sequence homology|Paralogues]] for S1PR5 Gene
- See also
- References
- Further reading
- External links
Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.
== Agonists == A-971432 Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)