SF3A3
Sign in to saveAlso known as PRP9, PRPF9, SAP61, SF3a60, splicing factor 3a subunit 3
Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.
In the Vinony graph
Within Vinony's link graph, SF3A3 is referenced by 2 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
SF3A3- Name
- splicing factor 3a subunit 3
- Type
- protein-coding
- Position
- 37,956,975–37,990,681 (−)
- Aliases
- PRP9, PRPF9, SAP61, SF3a60
- Ensembl
- ENSG00000183431
- RefSeq RNA
- NM_001320830.2, NM_006802.4
- RefSeq protein
- NP_001307759.1, NP_006793.1
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
splicing factor 3a subunit 3
- Symbol
- SF3A3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:37,956,975-37,990,681
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SF3A3 PDB 2dt7.png
Show 7 more facts
- HomoloGene ID
- 4949
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10946
- genomic end
- 37990075
- genomic start
- 38422647
- chromosome
- human chromosome 1
- cytogenetic location
- 1p34.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
Excerpted from Wikipedia’s “SF3A3” article, available under the CC BY-SA 4.0 licence.