GTF3A

Also known as AP2, TFIIIA, general transcription factor IIIA

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.

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Vinony's link graph records 816 inbound references to GTF3A, and connects out to PubMed, Ensembl genome database project and homeobox.

Vinony files it under Genes on human chromosome 13 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

GTF3A

Name: general transcription factor IIIA
Type: protein-coding
Aliases: AP2, TFIIIA

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

general transcription factor IIIA

Symbol: GTF3A
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:27,424,584-27,435,823
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 55630
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2971
genomic end: 28009958
genomic start: 27424619
chromosome: human chromosome 13
cytogenetic location: 13q12.2

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Encyclopedic overview

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Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.

It was first purified and identified as the first mammalian gene-specific activator by Robert G. Roeder in 1980, and later characterized by Wolffe and Brown in 1988.

Excerpted from Wikipedia’s “GTF3A” article, available under the CC BY-SA 4.0 licence.