SF3B4
Sign in to saveAlso known as AFD1, Hsh49, SAP49, SF3b49, splicing factor 3b subunit 4
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.
In the Vinony graph
Vinony's link graph records 7 inbound references to SF3B4, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 6 Wikipedia language editions.
Gene data
SF3B4- Name
- splicing factor 3b subunit 4
- Type
- protein-coding
- Position
- 149,923,317–149,928,268 (−)
- Aliases
- AFD1, Hsh49, SAP49, SF3b49
- Ensembl
- ENSG00000143368
- RefSeq RNA
- NM_005850.5, XM_054333793.1
- RefSeq protein
- NP_005841.1, XP_054189768.1
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
splicing factor 3b subunit 4
- Symbol
- SF3B4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:149,923,317-149,928,268
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SF3B4 PDB 1x5t.png
Show 8 more facts
- HomoloGene ID
- 134086
- exact match
- identifiers.org/ncbigene/10262
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 1
- genomic start
- 149895209
- genomic end
- 149927803
- cytogenetic location
- 1q21.2
- genetic association
- Nager acrofacial dysostosis
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Disease associations
- Interactions
- References
- Further reading
- External links
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.
== Function ==
Excerpted from Wikipedia’s “SF3B4” article, available under the CC BY-SA 4.0 licence.