Structure via PubChem · Public domain (PubChem)
simfibrate
Sign in to saveAlso known as cholesolvin
Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.
Chemical data
- Formula
- C23H26Cl2O6
- Molecular weight
- 469.4 g/mol
- IUPAC name
- 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate
- SMILES
- CC(C)(C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl)OC2=CC=C(C=C2)Cl
- InChIKey
- JLRNKCZRCMIVKA-UHFFFAOYSA-N
- XLogP
- 6.2
- Polar surface area
- 71.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 468.111
Show 3 more facts
- chemical formula
- C₂₃H₂₆Cl₂O₆
- canonical SMILES
- CC(C)(C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl)OC2=CC=C(C=C2)Cl
- Commons category
- Simfibrate
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox | Watchedfields = changed | verifiedrevid = 464391792 | IUPAC_name = Propane-1,3-diyl bis[2-(4-chlorophenoxy)-2-methylpropanoate] | image = Simfibrate.svg | image_class = skin-invert-image
| tradename = Cholesolvin | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
Excerpted from Wikipedia’s “simfibrate” article, available under the CC BY-SA 4.0 licence.
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