سیم‌فیبرات

Also known as cholesolvin

Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia. The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.

Chemical data

Formula: C23H26Cl2O6
Molecular weight: 469.4 g/mol
IUPAC name: 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl 2-(4-chlorophenoxy)-2-methylpropanoate
SMILES: CC(C)(C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl)OC2=CC=C(C=C2)Cl
InChIKey: JLRNKCZRCMIVKA-UHFFFAOYSA-N
XLogP: 6.2
Polar surface area: 71.1 Å²
H-bond donors: 0
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: cardiovascular disease

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 468.111

Show 3 more facts

chemical formula: C₂₃H₂₆Cl₂O₆
canonical SMILES: CC(C)(C(=O)OCCCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl)OC2=CC=C(C=C2)Cl
Commons category: Simfibrate

Sources (2)

via Wikidata · CC0

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via Wikidata sitelinks · CC0