SQSTM1
Sign in to saveAlso known as A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3
protein-coding gene in the species Homo sapiens
Gene data
SQSTM1- Name
- sequestosome 1
- Type
- protein-coding
- Position
- 179,806,398–179,838,078 (+)
- Aliases
- A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62
- Ensembl
- ENSG00000161011
- RefSeq RNA
- NM_001142298.2, NM_001142299.2, NM_003900.5
- RefSeq protein
- NP_001135770.1, NP_001135771.1, NP_003891.1
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sequestosome 1
- Symbol
- SQSTM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:179,806,398-179,838,078
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SQSTM1 PDB 1q02.png
Show 8 more facts
- HomoloGene ID
- 31202
- genetic association
- Paget's disease of bone
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8878
- genomic start
- 179233388
- chromosome
- human chromosome 5
- genomic end
- 179265078
- cytogenetic location
- 5q35.3
Sources (7)
via Wikidata · CC0