STRADA

Also known as LYK5, NY-BR-96, PMSE, STRAD, Stlk, STE20-related kinase adaptor alpha, STRAD alpha, STE20 related adaptor alpha

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.

Gene data

STRADA

Name: STE20 related adaptor alpha
Type: protein-coding
Position: 63,682,336–63,741,986 (−)
Aliases: LYK5, NY-BR-96, PMSE, STLK5, STRAD, STRAD alpha, Stlk
Ensembl: ENSG00000266173
RefSeq RNA: NM_001003786.3, NM_001003787.4, NM_001003788.3, NM_001165969.2, NM_001165970.2
RefSeq protein: NP_001003786.1, NP_001003787.1, NP_001003788.1, NP_001159441.1, NP_001159442.1

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009].

Pathways

mTOR signaling pathway - Homo sapiens (human)AMPK signaling pathway - Homo sapiens (human)Signal Transduction MTOR signalling Energy dependent regulation of mTOR by LKB1-AMPK AMP-activated protein kinase (AMPK) signaling Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

via MyGene.info

Gene · Ensembl

STE20 related adaptor alpha

Symbol: STRADA
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:63,682,336-63,742,005
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: PDB 1upk EBI.jpg

Show 5 more facts

HomoloGene ID: 12448
exact match: identifiers.org/ncbigene/92335
genomic end: 63741986
genomic start: 63682336
cytogenetic location: 17q23.3

Sources (5)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Disease linkage
Interactions
References
Further reading

Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.

== Function == Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induced G1 phase arrest. STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.