SUMF2
Sign in to saveAlso known as pFGE, sulfatase modifying factor 2
Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene.
Gene data
SUMF2- Name
- sulfatase modifying factor 2
- Type
- protein-coding
- Aliases
- pFGE
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
sulfatase modifying factor 2
- Symbol
- SUMF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:56,064,002-56,087,955
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein SUMF2 PDB 1y4j.png
Show 5 more facts
- HomoloGene ID
- 41037
- exact match
- identifiers.org/ncbigene/25870
- genomic end
- 56148363
- genomic start
- 56131695
- cytogenetic location
- 7p11.2
Sources (4)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene.
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.