SYT1
Sign in to saveAlso known as P65, SVP65, SYT, synaptotagmin 1, BAGOS
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.
In the Vinony graph
Vinony's link graph records 231 inbound references to SYT1, and connects out to COPII, AP-type membrane coat adaptor complex and PubMed.
It is catalogued under the topic Genes on human chromosome 12.
Vinony links it to 4 Wikipedia language editions.
Gene data
SYT1- Name
- synaptotagmin 1
- Type
- protein-coding
- Position
- 78,863,650–79,452,009 (+)
- Aliases
- BAGOS, P65, SVP65, SYT
- Ensembl
- ENSG00000067715
- RefSeq RNA
- NM_001135805.2, NM_001135806.2, NM_001291901.2, NM_001415938.1, NM_001415939.1
- RefSeq protein
- NP_001129277.1, NP_001129278.1, NP_001278830.1, NP_001402867.1, NP_001402868.1
This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
synaptotagmin 1
- Symbol
- SYT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:78,863,650-79,452,009
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SYT1 PDB 1byn.png
Show 9 more facts
- HomoloGene ID
- 4122
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6857
- genomic start
- 79257773
- chromosome
- human chromosome 12
- genomic end
- 79845788
- cytogenetic location
- 12q21.2
- expressed in
- cerebellar vermis
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Function
- Interactions
- Clinical Significance
- References
- Further reading
Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.
== Function == Synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions (Ca2+) in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. [Supplied by OMIM]
Excerpted from Wikipedia’s “SYT1” article, available under the CC BY-SA 4.0 licence.