TANK

Name

TRAF family member associated NFKB activator

Type

protein-coding

Position

161,136,908–161,236,230 (+)

Aliases

I-TRAF, ITRAF, TRAF2

Ensembl

ENSG00000136560

RefSeq RNA

NM_001199135.3, NM_004180.3, NM_133484.2, XM_005246207.4, XM_024452335.2

RefSeq protein

NP_001186064.1, NP_004171.2, NP_597841.1, XP_005246264.3, XP_024308103.1

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

via MyGene.info

Gene · Ensembl

TRAF family member associated NFKB activator

Symbol

TANK

Biotype

Protein coding

Organism

Homo sapiens

Location

2:161,136,908-161,236,568

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

PDB 1kzz EBI.jpg

via Wikidata · CC0