TBK1

Name

TANK binding kinase 1

Type

protein-coding

Position

64,452,090–64,502,116 (+)

Aliases

AIARV, FTDALS4, IIAE8, NAK, T2K

Ensembl

ENSG00000183735

RefSeq RNA

NM_001445662.1, NM_013254.4, NR_201535.1, NR_201536.1, NR_201537.1

RefSeq protein

NP_001432591.1, NP_037386.1, XP_005268866.1, XP_005268867.1, XP_054227832.1

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021].

via MyGene.info

Gene · Ensembl

TANK binding kinase 1

Symbol

TBK1

Biotype

Protein coding

Organism

Homo sapiens

Location

12:64,452,090-64,502,116

Strand

Forward (+)

Assembly

GRCh38