Structure via PubChem · Public domain (PubChem)
tipranavir
Sign in to saveAlso known as U-140690, TPV, 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
Tipranavir (TPV), or tipranavir disodium, is a nonpeptidic protease inhibitor (PI) manufactured by Boehringer Ingelheim under the trade name Aptivus . It is administered with ritonavir in combination therapy to treat HIV infection.
In the Vinony graph
Vinony's link graph records 138 inbound references to tipranavir, and connects out to tenofovir alafenamide, nucleoside analogue and liver.
It is catalogued under topics including 4-Pyrones, CYP2D6 inhibitors and Dihydropyrans.
Vinony links it to 18 Wikipedia language editions.
Chemical data
- Formula
- C31H33F3N2O5S
- Molecular weight
- 602.7 g/mol
- IUPAC name
- N-[3-[(1R)-1-[(2R)-4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide
- SMILES
- CCC[C@]1(CC(=C(C(=O)O1)[C@H](CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=CC=C4
- InChIKey
- SUJUHGSWHZTSEU-FYBSXPHGSA-N
- XLogP
- 7
- Polar surface area
- 114 Ų
- H-bond donors
- 2
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2005
- Admin. routes
- oral
- Indications
- HIV infection, viral disease, hemorrhage
via ChEMBL · EBI
Research
512 papers- Tipranavir.2012
- Tipranavir.2006
- Tipranavir.Drugs · 2003
- Tipranavir.Drugs of today (Barcelona, Spain : 1998) · 2005
- Tipranavir: PNU 140690, tipranivir.Drugs in R&D · 2006
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 602.206
- Has use
- medication
Show 10 more facts
- subject has role
- bactericide
- chemical formula
- C₃₁H₃₃F₃N₂O₅S
- significant drug interaction
- atorvastatin
- canonical SMILES
- CCCC1(CC(=C(C(=O)O1)C(CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=CC=C4
- isomeric SMILES
- CCC[C@]1(CC(=C(C(=O)O1)[C@H](CC)C2=CC(=CC=C2)NS(=O)(=O)C3=NC=C(C=C3)C(F)(F)F)O)CCC4=CC=CC=C4
- World Health Organisation international non-proprietary name
- tipranavir
- defined daily dose
- 1
- medical condition treated
- HIV infection
- Commons category
- Tipranavir
- legal status (medicine)
- boxed warning
Sources (7)
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
{{Drugbox | Verifiedfields = changed | verifiedrevid = 470610685 | image = File:Tipranavir structure 2.svg | image_class = skin-invert-image | width = 275 | alt =
| pronounce = | tradename = Aptivus | Drugs.com = | MedlinePlus = a606009 | licence_EU = yes | DailyMedID = Tipranavir | licence_US = Tipranavir | pregnancy_AU = B3 | pregnancy_US = C | routes_of_administration = By mouth (soft capsules) | ATC_prefix = J05 | ATC_suffix = AE09 | ATC_supplemental =
Excerpted from Wikipedia’s “tipranavir” article, available under the CC BY-SA 4.0 licence.