Also known as ASC-1, ASC1, HsT17391, ZC2HC5, SMABF1, thyroid hormone receptor interactor 4, MDCDC
Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016].
via MyGene.info
Activating signal cointegrator 1 is a protein in humans that is encoded by the TRIP4 gene.
==Interactions== TRIP4 has been shown to interact with Nuclear receptor coactivator 1.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).