UBE4A
Sign in to saveAlso known as E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.
In the Vinony graph
Within Vinony's link graph, UBE4A is referenced by 3 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 6 Wikipedia language editions.
Gene data
UBE4A- Name
- ubiquitination factor E4A
- Type
- protein-coding
- Position
- 118,359,578–118,399,211 (+)
- Aliases
- E4, NEDHMS, UBOX2, UFD2
- Ensembl
- ENSG00000110344
- RefSeq RNA
- NM_001204077.2, NM_004788.4
- RefSeq protein
- NP_001191006.1, NP_004779.2
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquitination factor E4A
- Symbol
- UBE4A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:118,359,578-118,399,211
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBE4A PDB 1wgm.png
Show 8 more facts
- HomoloGene ID
- 3517
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9354
- chromosome
- human chromosome 11
- genomic start
- 118359600
- genomic end
- 118269926
- cytogenetic location
- 11q23.3
- expressed in
- inferior ganglion of vagus nerve
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
Excerpted from Wikipedia’s “UBE4A” article, available under the CC BY-SA 4.0 licence.