Also known as E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
via MyGene.info
~1 min read
Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).