utrophin

Also known as DRP-1, dystrophin-related protein 1, UTRN

Utrophin is a protein that in humans is encoded by the UTRN gene. The name is a short form for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6.

In the Vinony graph

Within Vinony's link graph, utrophin is referenced by 282 other articles, and connects out to PubMed, human chromosome 6 and protein domain.

Vinony files it under Cell adhesion proteins, Cytoskeleton and Genes on human chromosome 6.

Its subject is documented across 8 Wikipedia language editions.

Protein · UniProt

Utrophin

Gene: UTRN
Organism: Homo sapiens (Human)
Length: 3,433 aa
Molecular mass: 394,466 Da
Evidence: 1: Evidence at protein level

May play a role in anchoring the cytoskeleton to the plasma membrane

3D-structureActin-bindingAlternative promoter usageCalciumCell membraneCytoplasmCytoskeletonMembrane

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Research

1,157 papers

Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy.Nature · 2025
Utrophin: a structural and functional comparison to dystrophin.Brain pathology (Zurich, Switzerland) · 1996
Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
[Utrophin, a way to cure Duchenne muscle dystrophy].Medecine sciences : M/S · 2004
Utrophin upregulation in Duchenne muscular dystrophy.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2005

via PubMed

Clinical Trials

1 registered

PHASE2TERMINATED
Proof of Concept Study to Assess Activity and Safety of SMT C1100 (Ezutromid) in Boys With Duchenne Muscular Dystrophy (DMD)Summit Therapeutics · NCT02858362

via ClinicalTrials.gov

Wikidata facts

Instance of: protein
Has part: WW domain

Show 2 more facts

cell component: extracellular exosome
found in taxon: Homo sapiens

Sources (5)

via Wikidata · CC0

~2 min read

Encyclopedic overview

9 sections

Contents

Discovery
Tissue distribution
Structure
Function
Clinical significance
See also
References
Further reading
External links

Utrophin is a protein that in humans is encoded by the UTRN gene. The name is a short form for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6.

== Discovery ==

Excerpted from Wikipedia’s “utrophin” article, available under the CC BY-SA 4.0 licence.