Structure via PubChem · Public domain (PubChem)
zotepine
Sign in to saveAlso known as Zoleptil®, 2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia. It has been used in Germany since 1990 (although it has been discontinued in Germany) and Japan since 1982.
Chemical data
- Formula
- C18H18ClNOS
- Molecular weight
- 331.9 g/mol
- IUPAC name
- 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethylethanamine
- SMILES
- CN(C)CCOC1=CC2=CC=CC=C2SC3=C1C=C(C=C3)Cl
- InChIKey
- HDOZVRUNCMBHFH-UHFFFAOYSA-N
- XLogP
- 4.8
- Polar surface area
- 37.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Research
319 papers- Zotepine for schizophrenia.The Cochrane database of systematic reviews · 2000
- Zotepine for schizophrenia.The Cochrane database of systematic reviews · 2006
- Zotepine versus other atypical antipsychotics for schizophrenia.The Cochrane database of systematic reviews · 2010
- Safety evaluation of zotepine for the treatment of schizophrenia.Expert opinion on drug safety · 2010
- Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis.Lancet (London, England) · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 331.079763
- Has use
- medication
Show 8 more facts
- defined daily dose
- 0.2
- chemical formula
- C₁₈H₁₈ClNOS
- canonical SMILES
- CN(C)CCOC1=CC2=CC=CC=C2SC3=C1C=C(C=C3)Cl
- World Health Organisation international non-proprietary name
- zotepine
- subject has role
- antipsychotics
- medical condition treated
- schizophrenia
- physically interacts with
- solute carrier family 6 member 4
- Commons category
- Zotepine
via Wikidata · CC0
~5 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Synthesis
- Society and culture
- Brand names
- See also
- References
- Further reading
Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia. It has been used in Germany since 1990 (although it has been discontinued in Germany) and Japan since 1982.
Zotepine is not approved for use in the United States, United Kingdom, Australia, Canada or New Zealand.
Excerpted from Wikipedia’s “zotepine” article, available under the CC BY-SA 4.0 licence.