adipogenesis
Sign in to savethumb|Histology features of a [[lipoblast, also known as an adipocyte precursor cell or preadipocyte.]] Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as lipoblasts or preadipocytes which lose the potential to differentiate to other types of cells such as chondrocytes, myocytes, and osteoblasts. Terminal differentiation is that preadipocytes differentiate into mature adipocytes. Adipocytes can arise either f
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Article
14 sectionsContents
- Introduction
- Differentiation
- Models of in vitro differentiation
- Transcriptional regulations
- PPARγ
- C/EBPs
- Transcriptional cascade
- Epigenetic regulation: TET1
- Other regulations
- Insulin and IGF1
- Wnt signaling
- BMPs
- Senescent cells
- References
thumb|Histology features of a [[lipoblast, also known as an adipocyte precursor cell or preadipocyte.]] Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as lipoblasts or preadipocytes which lose the potential to differentiate to other types of cells such as chondrocytes, myocytes, and osteoblasts. Terminal differentiation is that preadipocytes differentiate into mature adipocytes. Adipocytes can arise either from preadipocytes resident in adipose tissue, or from bone-marrow derived progenitor cells that migrate to adipose tissue.
thumb|right|260px|Differentiated Adipocyte stained with Oil Red O