DEPTOR

Also known as DEP.6, DEPDC6, DEP domain containing MTOR-interacting protein, DEP domain containing MTOR interacting protein

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene.

Gene data

DEPTOR

Name: DEP domain containing MTOR interacting protein
Type: protein-coding
Position: 119,873,717–120,050,918 (+)
Aliases: DEP.6, DEPDC6, hDEPTOR
Ensembl: ENSG00000155792
RefSeq RNA: NM_001283012.2, NM_022783.4
RefSeq protein: NP_001269941.1, NP_073620.2

Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

negative regulation of protein kinase activity G protein-coupled receptor signaling pathway positive regulation of autophagy negative regulation of TOR signaling negative regulation of TOR signaling intracellular signal transduction negative regulation of cell size negative regulation of TORC2 signaling

Molecular function

protein kinase inhibitor activity guanyl-nucleotide exchange factor activity GTPase activator activity protein binding protein serine/threonine kinase inhibitor activity protein serine/threonine kinase inhibitor activity phosphatidic acid binding

Cellular component

lysosomal membrane lysosomal membrane plasma membrane

Pathways

Autophagy - animal - Homo sapiens (human)mTOR signaling pathway - Homo sapiens (human)Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling Pathways in clear cell renal cell carcinoma Regulatory circuits of the STAT3 signaling pathway Fragile X Syndrome Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway Autophagy

via MyGene.info

Gene · Ensembl

DEP domain containing MTOR interacting protein

Symbol: DEPTOR
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:119,873,670-120,051,577
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 32551
exact match: identifiers.org/ncbigene/64798
genomic end: 120050918
genomic start: 120885957
cytogenetic location: 8q24.12

Sources (3)

via Wikidata · CC0

~1 min read

Article

6 sections

Contents

Structure
Function
Metabolism
Clinical cancer
References
Further reading

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene.

== Structure ==