KLF2
Sign in to saveAlso known as LKLF, Kruppel-like factor 2, Kruppel like factor 2
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.
Gene data
KLF2- Name
- KLF transcription factor 2
- Type
- protein-coding
- Aliases
- LKLF
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017].
via MyGene.info
Gene · Ensembl
KLF transcription factor 2
- Symbol
- KLF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:16,324,613-16,328,685
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 133978
- exact match
- identifiers.org/ncbigene/10365
- genomic end
- 16328685
- genomic start
- 16324826
- cytogenetic location
- 19p13.11
via Wikidata · CC0
~9 min read
Article
13 sectionsContents
- Discovery
- Structure
- Gene expression
- Mouse knockout
- Function
- Lung development
- Embryonic erythropoiesis
- Endothelial physiology
- T-cell differentiation
- Adipogenesis
- See also
- References
- External links
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.
== Discovery ==