آدیپونکتین
Sign in to saveAlso known as 30 kDa adipocyte complement-related protein, GBP-28, apM-1, Gelatin-binding protein, adipocyte complement-related 30 kDa protein, ADIPOQ, adipose specific collagen-like factor, apM1
Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown. In humans, it is encoded by the ADIPOQ gene and is produced primarily in adipose tissue, but also in muscle and even in the brain.
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Vinony's link graph records 215 inbound references to آدیپونکتین, and connects out to PubMed, type 2 diabetes and insulin resistance.
It sits within the topics Adiponectin receptor agonists, Genes on human chromosome 3 and Obesity.
Vinony links it to 27 Wikipedia language editions.
Protein · UniProt
Adiponectin
- Gene
- ADIPOQ
- Organism
- Homo sapiens (Human)
- Length
- 244 aa
- Molecular mass
- 26,414 Da
- Evidence
- 1: Evidence at protein level
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by…
Swiss-Prot (reviewed) · via UniProt
Research
27,916 papers- Adiponectin Regulation and Function.Comprehensive Physiology · 2018
- Adiponectin, exercise and eye diseases.International review of neurobiology · 2019
- Adiponectin and Its Isoforms in Pathophysiology.Advances in clinical chemistry · 2018
- Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space.Physiology (Bethesda, Md.) · 2021
- Adiponectin-mediated regulation of the adiponectin cascade in cardiovascular disease: Updates.Biochemical and biophysical research communications · 2024
via PubMed
Clinical Trials
157 registered- UNKNOWNEvaluation of Endocrine and Metabolic Parameters in the New Diagnostic Phenotypes of Polycystic Ovary SyndromeUniversidad Nacional de Córdoba · NCT00784615
- COMPLETEDThe Effect of Aerobic Exercise on Selective Biomarkers of Patients With CancerIzmir Bakircay University · NCT07048847
- PHASE1COMPLETEDChanges in Adiponectin and Cardiovascular Disease Risk Factors in Overweight PatientsUniversity of Isfahan · NCT02882672
- NARECRUITINGComparison of Two Different Intensity Exercises on Young Women With ObesityAhi Evran University Education and Research Hospital · NCT06610955
- COMPLETEDRecombinant Human Erythropoietin Dose, Serum Adiponectin, and All-Cause Mortality in Patients Beginning HemodialysisHamamatsu University · NCT00457561
- PHASE3COMPLETEDEffect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese ChildrenIsfahan University of Medical Sciences · NCT01886495
Wikidata facts
- Instance of
- protein
- Has part
- Collagen triple helix repeat
Show 4 more facts
- P352
- Tomohon
- biological process
- signal transduction
- found in taxon
- Felis catus
- exact match
- purl.uniprot.org/uniprot/Q15848
via Wikidata · CC0